I've seen people discuss it on facebook. Seems like the oil pan needs to be changed to a rear sump, a transmission adapter needs procured to get to the 4L60, and of course motor mounts will need to be fabricated.
Here's a Nailhead on an S-10 frame, albeit with an International body: https://www.jalopyjournal.com/forum/threads/nailhead-in-an-intl-via-an-s10-and-custom-mounts.279200/